APC Antigen - presenting cell

Downregulation of IL-12 Production in Healthy Non-Responder Neonates to Recombinant Hepatitis B Vaccine

A proportion of healthy neonates and adults fail to develop a protective antibody response to recombinant hepatitis B (HB) vaccine. Unresponsiveness to vaccination could be attributed to defect in a number of immunological regulatory mechanisms. In this study, IL-12 was quantitated in culture supernatant following in vitro stimulation of peripheral blood mononuclear cells isolated from a group ...

Cell Interactions in Humoral Responses: the Carrier Effect

A primary humoral immune response requires the cooperation of three cell types, an ANTIGEN-PRESENTING CELL (APC, typically a dendritic cell or macrophage), a T-HELPER CELL (TH2), and a B-CELL. The APC/T-CELL interaction involves the recognition of MHC Class II-bound peptide by the T-cell receptor, and the participation of the accessory molecule CD4. The same principles apply to secondary humora...

Immunological agnosis: a state that derives from T suppressor cell inhibition of antigen-presenting cells.

The biologically active mediators of antigen-specific T suppressor cells can combine with antigen on cells that are specialized to present antigen (APC) and render these APC incapable of presenting not only the specific antigen that the product of the T suppressor cell sees but also any other antigen in or on the APC. Thus, antigen-bearing suppressed APC fail to activate either the helper or su...

Cognate MHC-TCR interaction leads to apoptosis of antigen-presenting cells.

Antigen presentation to T lymphocytes has been characterized extensively in terms of T lymphocyte activation and eventual cell death. In contrast, little is known about the consequences of antigen presentation for the antigen-presenting cell (APC). We have determined the outcome of major histocompatibility complex class II-restricted peptide presentation to a specific T cell. We demonstrate tha...

Restriction molecules involved in the interaction of T cells with allogeneic antigen-presenting cells

The proliferative responses of T cells, depleted of alloreactive cells, were tested upon stimulation by antigens presented on allogeneic antigen-presenting cells (APC). Restriction molecules involved in these responses were identified by inhibition of T cell proliferation with monoclonal antibodies against A(A alpha A beta) and E(E alpha E beta) molecules of the APC. The responses to all three ...

The Immunomodulatory Effect of Cyclophosphamide on Regulation of T-Cell Subsets and Antigen Presenting Cells.